Rapamycin is a promising
new anti-aging medicine, known
to increase lifespan in mice, by preventing tumour growth
Rapamycin has been used in clinical
trials for treating cancer, and as an immunosuppressant to help prevent rejection in organ
100 × 1mg tablets
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Rapamycin was originally discovered in
soil samples from Easter Island, as a bacterial by-product. As Easter Island is locally known as Rapa Nui, hence the name of Rapamycin. Back in 2014, Novartis was looking to increase response
to flu vaccines by people over 65. The drug they tested was a derivative of rapamycin and seemed to improve
immune response in those tested, responding like a young person's immunity - more effectively.
It was discovered that this new
compound, produced by soil bacteria native to Easter Island or Rapa Nui, could help the immune system in the elderly act younger. By
discovering that it has many positive effects on the immune system, rapamycin-based drugs are already used in
treating cancer and in organ transplants to suppress the immune system, preventing organ
mTOR inhibitor increases mice lifespan
Rapamycin inhibits protein called mTOR
(mechanistic Target of Rapamycin). In
laboratory experiments Rapamycin extended the lifespan of yeasts, worms and mice. It increased mice lifespan 9% in
males and 13% in females.
Subsequently, Rapamycin was also tested
on dogs on the University of Washington trials. After 10-week period, these showed an improved heart functionality
in the dogs that were given this medicine.
The basic effects of Rapamycin seem to
be able to counteract some of the effects of aging, which is what makes it a potential antiaging medicine. One of
its positive effects is its ability to remove dead (senescent) cells from the body. These dead cells
contribute to age-related pathology and loss of function. By removing them from the body, it improves its
physiological function and extends longevity.
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Being a cutting-edge anti-aging medication, it's suggested to take it
in very small dosages. Depending on the advice from your doctor, you
should keep your dosages low. That would be 1mg to 5mg per week. See
dosage instructions that come with the Rapamune pack.